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目的：探讨 Ｌ岩藻糖在肿瘤免疫中所起的作用。方法：对６６ 例成人口腔恶性肿瘤患者和 ５５ 名健康成人，采用浅见直法测定其血清 Ｌ岩藻糖含量。同时对其中的３０ 例患者和正常人通过测 Ｏ Ｄ５７０值来计算细胞毒指数。结果：患者组的血清 Ｌ岩藻糖含量为（１８１７±５９６）μｇ／ Ｌ，细胞毒指数为（０６３±０１１）。明显高于对照组的（８８±１９４）μｇ／ Ｌ及（０１１±００５）， Ｐ＜ ００１，两者相关系数ｒ＝ － ０４３，ｔｒ＝ ２２９， Ｐ＜ ００５。结论：口腔癌患者血清 Ｌ岩藻糖含量及肿瘤坏死因子活性均较正常人明显增高，且两者间呈较密切的负相关关系，提示 Ｌ岩藻糖在肿瘤免疫中可能起某种抑制性作用。
Objective: To investigate the role of L-fucose in tumor immunity. Methods: 66 cases of adult patients with oral malignant tumors and 55 healthy adults, using shallow see straight method to determine the serum L fucose content. At the same time, among 30 patients and normal subjects, the cytotoxic index was calculated by measuring the value of O D570. Results: The serum Lfucose content of the patients was (1817 ± 596) μg / L and the cytotoxicity index was (063 ± 011). (88 ± 194) μg / L and (11 ± 005), P <001, respectively, the correlation coefficient between the two was r = -043 and tr = 2 29, P <005. Conclusion: The serum Lfucose content and tumor necrosis factor activity in patients with oral cancer were significantly higher than those in normal people, and there was a close negative correlation between them, suggesting that Lfucose may play a role in tumor immunity Inhibitory effect