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目的为了更好地开展居民大肠癌筛查,分析比较危险因素筛查问卷和大便潜血检查(FOBT)两种方法的检出率,以及与病理诊断相比的灵敏度和特异度。方法对2014年对广东省广州市越秀区的1 501名居民进行了大肠癌筛查结果进行分析。采用了危险因素筛查问卷和FOBT检测两种方法。结果有1 335名居民接受调查问卷筛查方法,共筛查出825位易患大肠癌的危险人群,检出率为61.8%。有704位居民接受FOBT方法,共检出67位为阳性,检出率9.5%。有1 153名居民接受肠镜检查和病理检查,筛查出636名居民有病变,阳性率为55.2%。筛查问卷方式检验大肠癌的灵敏度为65.5%,特异度为10.3%,ROC曲线下面积为0.58;FOBT检验方法灵敏度为11.1%,特异度为84.8%,ROC曲线下面积为0.61。结论此次筛查问卷和FOBT方法效果均不够理想,建议问卷法+FOBT检测筛查兼顾灵敏度和特异度。
Objective To better carry out residential colorectal cancer screening, analysis and comparison of risk factors screening questionnaire and fecal occult blood test (FOBT) two detection methods, and compared with the pathological diagnosis of sensitivity and specificity. Methods A total of 1 501 residents of Yuexiu District of Guangzhou City in Guangdong Province in 2014 were analyzed for colorectal cancer screening results. Using risk factor screening questionnaire and FOBT detection of two methods. Results A total of 1 335 residents were enrolled in the questionnaire screening method. A total of 825 people at risk of colorectal cancer were screened out, with a detection rate of 61.8%. 704 residents received FOBT method, a total of 67 were positive, the detection rate of 9.5%. A total of 1 153 residents underwent colonoscopy and pathological examination, screening out 636 residents with lesions, the positive rate was 55.2%. The sensitivity of screening test for colorectal cancer was 65.5%, the specificity was 10.3%, and the area under the ROC curve was 0.58. The sensitivity and specificity of FOBT test were 11.1% and 84.8%, respectively. The area under the ROC curve was 0.61. Conclusion The screening questionnaire and FOBT method are not satisfactory results, it is recommended that the questionnaire + FOBT screening both sensitivity and specificity.