论文部分内容阅读
为探讨实验性心力衰竭（简称心衰）形成持续性心房颤动（简称房颤）的可行性，用２００～２５０ｐｐｍ的频率以ＶＯＯ方式起搏犬心室３～７周形成实验性心衰，在犬清醒状态下观察心衰前、后刺激诱发的房性快速心律失常。快速起搏右室３～７周，８条犬均发生充血性心衰，３周时体重由心衰前的２８±６ｋｇ降至２４±４ｋｇ（Ｐ＜０．０５）；左室射血分数由０．６４±０．０６降至０．２３±０．０９（Ｐ＜０．０１），右房直径由２５±３ｍｍ增至３６±６ｍｍ（Ｐ＜０．０１），心房不应期由１１６±５ｍｓ增至１３７±１２ｍｓ（Ｐ＝０．０１），不应期离散度无显著性改变（１６±１２ｍｓｖｓ２０±９ｍｓ，Ｐ＝０．２０），心房平均传导时间亦无显著性变化（６１±１９ｍｓｖｓ６６±２４ｍｓ，Ｐ＝０．２０）。１条犬于起搏后第６周夜间突然死亡。心衰前，８条犬均未诱发心房扑动，４条犬诱发短暂房颤；心衰后，８条犬均可反复诱发心房扑动和持续性房颤（持续时间超过１５ｍｉｎ，平均周长９５±５ｍｓ），最长者持续２４ｈ以上。结果表明起搏心室导致犬心衰可形成非瓣膜病性慢性房颤的实验模型。
To investigate the feasibility of establishing continuous atrial fibrillation (HF) in experimental heart failure (HF), experimental heart failure was induced by VOO for 3-7 weeks with a frequency of 200-250 ppm, Awake state observed before and after heart failure induced atrial tachyarrhythmias. Rapid pacing right ventricular 3 to 7 weeks, 8 dogs were congestive heart failure, 3 weeks before the body weight loss from 28 ± 6kg to 24 ± 4kg (P <0.05); left ventricular ejection fraction From 0.64 ± 0.06 to 0.23 ± 0.09 (P <0.01), the diameter of the right atrium increased from 25 ± 3 mm to 36 ± 6 mm (P <0.01), and the atrial refractory period was increased from 116 ± 5 ms to 137 ± 12 ms (P = 0.01). There was no significant change in refractory period dispersion (16 ± 12 ms vs 20 ± 9 ms, P = 0.20) and no significant change in mean atrial conduction time ± 19 ms vs 66 ± 24 ms, P = 0.20). One dog died suddenly during the sixth week after pacing. Atrial fibrillation was not induced in 8 dogs and transient atrial fibrillation in 4 dogs before heart failure. Atrial fibrillation and persistent atrial fibrillation were induced repeatedly in all 8 dogs (duration of more than 15 min, average circumference 95 ± 5ms), the longest lasting more than 24h. The results show that pacing ventricular canine heart failure can lead to non-valvular chronic atrial fibrillation experimental model.