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目的探讨腺苷蛋氨酸对妊娠期肝内胆汁淤积症(ICP)患者瘙痒程度及肝功能的影响。方法选择2014年12月—2015年10月接受治疗的妊娠期肝内胆汁淤积症患者70例为研究对象,随机分为对照组和观察组,均35例。对照组实施常规治疗方案,在此基础上观察组联合应用腺苷蛋氨酸进行治疗,比较两组瘙痒程度及肝功能情况。结果两组患者治疗前TBA、ALT、AST、TB、DB差异无统计学意义(P>0.05);治疗后,观察组患者TBA、ALT、AST、TB、DB较对照组明显降低,差异有统计学意义(P<0.05);两组治疗前瘙痒程度差异无统计学意义(P>0.05);治疗后观察组患者瘙痒程度较对照组明显降低,差异有统计学意义(P<0.05)。结论腺苷蛋氨酸能够有效改善妊娠期肝内胆汁淤积症患者瘙痒程度及肝功能情况,疗效显著,值得推广。
Objective To investigate the effect of adenosine methionine on pruritus and liver function in patients with intrahepatic cholestasis of pregnancy (ICP). Methods Seventy patients with intrahepatic cholestasis of pregnancy who were treated from December 2014 to October 2015 were selected as the research object and randomly divided into control group and observation group, all of which were 35 cases. The control group to implement conventional treatment programs, on the basis of observation group combined adenosine methionine treatment, pruritus and liver function were compared between the two groups. Results There was no significant difference in TBA, ALT, AST, TB and DB between the two groups before treatment (P> 0.05). After treatment, TBA, ALT, AST, TB and DB in the observation group were significantly lower than those in the control group (P <0.05). There was no significant difference in pruritus between the two groups before treatment (P> 0.05). The degree of pruritus in the observation group was significantly lower than that in the control group after treatment (P <0.05). Conclusions Adenosine methionine can effectively improve pruritus degree and liver function in patients with intrahepatic cholestasis of pregnancy. The therapeutic effect is significant and worthy of promotion.