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报告22例系膜性IgM肾病(IgMN),占同期原发性肾小球疾病(肾活检证实)总数的13.92%。临床表现为肾病综合征(NS)15例,单纯性蛋白尿5例,蛋白尿伴镜下血尿2例。血清IgM明显升高者16例,其中1例最高达4.09g/L。病理检查全部病例肾小球系膜区以IgM沉积为主,其中20例为系膜增生性肾炎,2例为微小病变。15例NS患者经激素或激素+CTX治疗后,完全缓解12例,部分缓解3例,复发6例。2例NS伴有急性肾功能衰竭患者,经配合血液透析治疗后肾功能恢复正常
Reported 22 cases of mesangial IgM nephropathy (IgMN), accounting for the same period of primary glomerular disease (renal biopsy confirmed) the total number of 13.92%. Clinical manifestations of nephrotic syndrome (NS) in 15 cases, simple proteinuria in 5 cases, proteinuria with microscopic hematuria in 2 cases. Serum IgM was significantly higher in 16 cases, of which 1 case up to 4.09g / L. Pathological examination of all cases of glomerular mesangial area to IgM deposition, of which 20 cases of mesangial proliferative glomerulonephritis, 2 cases of minimal changes. Fifteen patients with NS were treated with hormones or hormone + CTX, 12 cases were completely relieved, 3 cases partially relieved and 6 cases relapsed. Two patients with NS accompanied by acute renal failure, renal function returned to normal after hemodialysis treatment