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目的探讨血清胱抑素-C(Cys-C)对AECOPD患者恢复情况的评估作用。方法回顾性分析2012年4月-2013年3月收治庆元县中医院呼吸科的108确诊为AECOPD的住院患者。并随机选择同期处于COPD稳定期的门诊患者共60例为对照组。分别记录两组的血清Cys-C水平、尿素氮、血清肌酐、肾小球滤过率及住院时间进行分析。结果AECOPD组患者血清Cys-C水平(1.13±0.25)mg/L明显高于对照组(0.94±0.22)mg/L,差异有统计学意义(t=4.921,P=0.000)。在AECOPD组中:Cys-C升高组患者血清尿素氮水平(7.00±1.51)mmol/L高于Cys-C正常组(5.19±1.92)mmol/L,差异有统计学意义(t=-4.637,P=0.000);Cys-C升高组患者住院时间(9.12±3.80)d大于Cys-C正常组(7.25±2.39)d,差异有统计学意义(t=-3.058,P=0.003)。AECOPD组患者Cys-C水平与血清尿素氮水平及住院时间呈正相关,有统计学意义(P<0.05)。结论 AECOPD患者早期肾功能的损害情况在一定程度上可通过血清Cys-C水平进行评估;血清Cys-C水平对AECOPD患者的住院时间亦有一定的影响,其可用于指导临床对AECOPD患者恢复情况进行评估。
Objective To investigate the effect of serum cystatin C (Cys-C) on the recovery of AECOPD patients. Methods A retrospective analysis of 108 hospitalized patients diagnosed with AECOPD admitted to the Department of Respiratory, Qingyuan Hospital of Traditional Chinese Medicine from April 2012 to March 2013 was performed. And randomly selected at the same period in stable COPD outpatients 60 patients as a control group. The levels of serum Cys-C, urea nitrogen, serum creatinine, glomerular filtration rate and hospital stay were recorded. Results The serum level of Cys-C (1.13 ± 0.25) mg / L in AECOPD group was significantly higher than that in control group (0.94 ± 0.22) mg / L, the difference was statistically significant (t = 4.921, P = 0.000). In the AECOPD group, the serum urea nitrogen level (7.00 ± 1.51) mmol / L in Cys-C elevated group was significantly higher than that in Cys-C normal group (5.19 ± 1.92 mmol / L) (t = -4.637 , P = 0.000). The length of hospital stay in patients with elevated Cys-C (9.12 ± 3.80) days was significantly higher than that in patients with normal Cys-C (7.25 ± 2.39 days) (t = -3.058, P = 0.003). The level of Cys-C in patients with AECOPD was positively correlated with serum urea nitrogen level and hospital stay (P <0.05). Conclusion The impairment of early renal function in patients with AECOPD may be assessed by serum Cys-C level. The serum Cys-C level also has some influence on the length of hospital stay in patients with AECOPD. It can be used to guide the clinical recovery of AECOPD patients to evaluate.