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线性自由能相关是物理有机化学研究的常用手段,其对于认识反应动力学行为,理解反应机理等方面发挥着不可替代的作用.自20世纪90年代以来,线性自由能相关在不对称催化研究中的应用取得快速发展,该类研究对于深入理解对映选择性控制因素以及指导手性催化剂开发和预测底物反应结果具有重要作用.尤其是近几年,多种新的取代基描述参数被应用于不对称催化中的线性自由能相关,同时新数学处理方法的引入使得该研究领域焕发出了蓬勃生机,并实现了物理有机研究对不对称催化反应发展的理论指导.本文系统介绍了线性自由能关系在不对称催化反应研究中的应用进展,并对其发展趋势进行了展望.
Linear free energy correlation is a commonly used method in physical organic chemistry research, which plays an irreplaceable role in understanding reaction kinetics and understanding reaction mechanism, etc. Since the 1990s, the linear free energy correlation has been widely used in asymmetric catalysis Of the rapid development of this type of research for the understanding of enantioselective control factors and to guide the development and prediction of chiral catalyst substrate reaction results play an important role, especially in recent years, a variety of new substituent description parameters are applied The linear free energy in the asymmetric catalysis is related, and the introduction of the new mathematical method makes the research field full of vitality and realizes the theoretical guidance of the physical and organic research on the development of asymmetric catalysis.In this paper, Can be used in asymmetric catalytic reaction research progress, and its development trend is forecasted.