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本文研究了多种红霉素电极。电极对于季铵的选择性可用诱导效应和空间位阻效应来定量说明,符合方程式logK_(ij)=a_1I-a_2Z/R+a_0,式中I为诱导效应指数,a_1,a_2,a_0为与电活性物有关的系数。建立了阳离子型药物电极K_(ij)对季铵烷基链碳原子数n的关系的一般数学模型:logK_(ij)=A/2.7~n+B/(0.80+1.26n)+C。证明:随着碳原子数增大,logK_(ij)趋于一极限值C。此处A,B,C为与电活性物有关的系数。
This article studies a variety of erythromycin electrodes. Electrode selectivity to quaternary ammonium induction effect can be used to quantify and steric effects, consistent with the equation logK_ (ij) = a_1I-a_2Z / R + a_0, where I is the induction effect index, a_1, a_2, a_0 for the electricity Active related coefficient. The general mathematical model of the relationship between the cationic drug K_ (ij) and the quaternary ammonium alkyl chain carbon number n is established: logK_ (ij) = A / 2.7 ~ n + B / (0.80 + 1.26n) + C. It is proved that logK_ (ij) tends to a limit value C as the number of carbon atoms increases. Here, A, B and C are the coefficients related to the electroactive substances.