【摘 要】
：
目的探讨射频热疗对兔膝骨关节炎形成过程中Ⅱ型胶原表达的影响。方法选取雄性家兔54只，采用改良Hulth造模法将其右后肢制成实验性膝关节骨关节炎模型。待造模成功后，将上述实验兔随机分为模型组、鹿瓜多肽组及射频热疗组。鹿瓜多肽组于制模后给予鹿瓜多肽肌肉注射，射频热疗组于制模后给予射频热疗治疗，模型组制模后未给予特殊处理。于治疗7 d、13 d及19 d时每组分别取6只实验兔处死，取右侧股骨内侧髁软骨，
【机 构】
：
014010 包头，内蒙古医科大学第三附属医院（内蒙古包钢医院）康复医学科,内蒙古医科大学,014010 包头，内蒙古医科大学第三附属医院（内蒙古包钢医院）骨科,014010 包头，内蒙古医科大学第三
论文部分内容阅读
目的探讨射频热疗对兔膝骨关节炎形成过程中Ⅱ型胶原表达的影响。
方法选取雄性家兔54只，采用改良Hulth造模法将其右后肢制成实验性膝关节骨关节炎模型。待造模成功后，将上述实验兔随机分为模型组、鹿瓜多肽组及射频热疗组。鹿瓜多肽组于制模后给予鹿瓜多肽肌肉注射，射频热疗组于制模后给予射频热疗治疗，模型组制模后未给予特殊处理。于治疗7 d、13 d及19 d时每组分别取6只实验兔处死，取右侧股骨内侧髁软骨，采用改良Mankins评分对其进行形态学评分；同时采用实时定量PCR技术检测各组实验兔右侧股骨内侧髁软骨组织Ⅱ型胶原含量。
结果经相同天数治疗后，发现模型组、鹿瓜多肽组及射频热疗组右侧股骨内侧髁软骨Mankins评分依次降低，软骨组织Ⅱ型胶原含量依次增高，组间差异均具有统计学意义(P<0.05)。射频热疗组随着治疗时间延长，其Mankins评分逐渐降低，软骨组织中Ⅱ型胶原含量逐渐增高，各时间点间差异均具有统计学意义(P<0.05)。
结论射频热疗治疗兔膝骨关节炎的疗效明显优于鹿瓜多肽，其治疗机制可能与显著增加软骨中Ⅱ型胶原含量有关。
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