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巨细胞病毒(CMV)是宫内病毒感染最常见类型。先天感染的平均发生率为所有流产中的1％,有症状的感染和胎儿损害通常由于母亲的原发感染。感染的新生儿中,5％～10％出生时有症状,如小于胎龄、紫癜、肝脾肿大、脉络膜视网膜炎、颅内钙化和听力减退。出生时无症状的婴儿中的,10％～15％将有后期发育问题。为评价人类CMV宫内传播与母亲感染时的孕龄是否有关,对自1988～1998年首次CMV感染的123例孕妇进行了回顾性研究。包括两方面资料:母亲通过特异的酶免检验血清转化证实初发CMV感染和新生儿通过尿液培养肯定诊断是否有宫内传播。85例孕妇每月连续检测,其余每3个月1次。根据血清CMV-IgG从阴性转化为阳性时
Cytomegalovirus (CMV) is the most common type of intrauterine virus infection. The average incidence of congenital infections is 1% of all abortions, and symptomatic infections and fetal damage are usually due to the mother’s primary infection. Infected newborns, 5% to 10% have symptoms at birth, such as less than gestational age, purpura, hepatosplenomegaly, chorioretinitis, intracranial calcification and hearing loss. Asymptomatic babies at birth, 10% to 15% will have late developmental problems. To evaluate whether human intrauterine transmission of CMV is associated with gestational age at the time of mother’s infection, a retrospective study of 123 pregnant women with first-time CMV infection from 1988 to 1998 was conducted. Including two aspects: the mother confirmed by a specific enzyme-seroconversion seroconversion CMV infection and newborn through urine culture positive diagnosis of intrauterine transmission. 85 cases of pregnant women monthly continuous testing, the remaining every 3 months 1 time. According to the serum CMV-IgG from negative to positive when