论文部分内容阅读
目的观察食管癌锁骨上淋巴结转移采用紫杉醇化疗配合放射治疗的临床疗效。方法对77例食管癌锁骨上淋巴结转移患者根据不同的治疗方法分为单纯放疗组(38例),均采用常规设野放疗法,放化疗组(39例),放疗方法与剂量同于单纯放疗组,化疗采用紫杉醇治疗。两组均随访3年。结果局部近期疗效放化疗组好于单纯放疗组。放化疗组与单纯放疗组1、2、3年生存率,放化疗组71.79%(28/39)、53.85%(21/39)、41.03%(16/39);单纯放疗组为52.63%(20/38)、28.94(11/38)、21.05%(8/38)。2、3年生存率差异有统计学意义(P<0.05)。结论食管癌锁骨上淋巴结转移患者采用紫杉醇每周同步放化疗治疗,既能提高近期疗效,又能提高远期生存率。
Objective To observe the clinical effect of paclitaxel combined with radiotherapy on supraclavicular lymph node metastasis of esophageal cancer. Methods 77 patients with supraclavicular lymph node metastasis of esophageal cancer were divided into radiotherapy group (38 cases) according to different treatment methods. All patients were treated with conventional radiotherapy and radiotherapy and chemotherapy group (39 cases). The radiotherapy method and dose were the same as radiotherapy Group, chemotherapy with paclitaxel treatment. Both groups were followed up for 3 years. Results Local short-term efficacy of radiotherapy and chemotherapy group was better than radiotherapy alone group. The 1, 2, 3-year survival rates of radiotherapy and chemotherapy group were 71.79% (28/39), 53.85% (21/39) and 41.03% (16/39) respectively in radiotherapy and chemotherapy group and 52.63% 20/38), 28.94 (11/38), 21.05% (8/38). The difference of 2-year and 3-year survival rates was statistically significant (P <0.05). Conclusion Paclitaxel concurrent chemoradiotherapy with radiotherapy in patients with supraclavicular lymph node metastasis of esophageal cancer can not only improve the short-term curative effect, but also improve the long-term survival rate.