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目的:探讨一氧化氮(NO)和一氧化氮合成酶(NOS)在妊高征发病过程中的致病机理及其临床意义。方法:用分光光度计对正常妊娠孕妇34例(正常妊娠组)和妊高征孕妇39例(妊高征组)的血浆 NO和脐静脉血管内皮细胞 NOS 活性进行测定比较。结果:与正常妊娠组相比,妊高征组产前 NO 活性明显低于对照组(P<0.01),重度妊高征的降低尤其显著,但产后各组无显著差异;妊高征组脐血 NO 水平和跻静脉血管内皮细胞 NOS 活性明显低于正常组;正常妊娠组脐血 NO 水平比其外周血高;妊高征患者外周血 NO 水平与平均动脉压(MAP)呈显著负相关。讨论:NO 的合成、释放减少及 NOS 活性降低在妊高征的病理生理过程中起着重要作用。
Objective: To investigate the pathogenesis and clinical significance of nitric oxide (NO) and nitric oxide synthase (NOS) during the pathogenesis of PIH. Methods: Plasma NO and umbilical vein endothelial nitric oxide synthase (NOS) activity in 34 pregnant women (normal pregnancy group) and 39 pregnant women with pregnancy induced hypertension (PIH) were measured by spectrophotometer. Results: Compared with the normal pregnancy group, the prenatal NO activity in the PIH group was significantly lower than that in the control group (P <0.01), especially in the PIH group, but there was no significant difference in postpartum groups The level of NO and the NOS activity in intervening venous endothelial cells were significantly lower than those in normal group. The level of NO in normal pregnant group was higher than that in peripheral blood. The level of NO in peripheral blood was negatively correlated with mean arterial pressure (MAP). Discussion: NO synthesis, reduced release and decreased activity of NOS play an important role in the pathophysiology of PIH.