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制备了Fe_3O_4@BSA磁性纳米功能材料,包裹在Fe_3O_4纳米粒子表面的牛血清白蛋白(BSA)主要起到分散剂和稳定剂的作用。通过傅里叶变换红外光谱、X射线衍射、透射电子显微镜及热重分析对合成的Fe_3O_4@BSA纳米粒子进行了表征和分析。结果表明,制备的Fe_3O_4@BSA纳米粒子中BSA质量分数约为18.9%。体外成像结果表明,随着Fe_3O_4@BSA纳米粒子浓度的增加,T2成像信号增强,具有明显的阴性造影效果。于0.5 T外磁场下,测得Fe_3O_4@BSA纳米粒子的横向弛豫率(transverse relaxivity,r2)为148.18 L/(mmol·s)。结果表明,Fe_3O_4@BSA纳米粒子能够作为一种潜在的T2类磁共振成像造影剂。
Fe_3O_4 @ BSA magnetic nanofunctional materials were prepared. Bovine serum albumin (BSA) coated on the surface of Fe_3O_4 nanoparticles mainly played the role of dispersant and stabilizer. The synthesized Fe_3O_4 @ BSA nanoparticles were characterized and analyzed by Fourier transform infrared spectroscopy, X-ray diffraction, transmission electron microscopy and thermogravimetric analysis. The results showed that the mass fraction of BSA in the prepared Fe 3 O 4 @ BSA nanoparticles was about 18.9%. The results of in vitro imaging showed that with the increase of the concentration of Fe 3 O 4 @ BSA nanoparticles, the signal of T2 imaging was enhanced and the negative contrast effect was obvious. Under the magnetic field of 0.5 T, the transverse relaxivity (r2) of Fe 3 O 4 @ BSA nanoparticles was 148.18 L / (mmol · s). The results show that Fe_3O_4 @ BSA nanoparticles can be used as a potential T2 MR imaging contrast agent.