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根据光谱分析确定了16个非天然产二萜生物碱1-16的结构。指定了化合物1-9、12-16的氢谱和1-10、12-14的碳谱。有趣的是N-氧化物8在乙酰氯(-5℃,2日)作用下生成去氮乙基化合物15。讨论了化合物12-16形成的可能反应机理。
The structures of 16 non-naturally occurring diterpene alkaloids 1-16 were determined based on spectral analysis. The hydrogen spectrum of compounds 1-9, 12-16 and the carbon spectrum of 1-10, 12-14 were assigned. It is interesting to note that N-oxide 8 forms deazaethyl compound 15 under the action of acetyl chloride (-5 ° C, day 2). The possible reaction mechanism for the formation of compounds 12-16 is discussed.