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目的:评价小剂量埃索美拉唑在预防反流性食管炎治愈后复发中的作用。方法:将2008年4月-2009年10月我院门诊及住院患者经质子泵抑制剂治疗后症状完全缓解的反流性食管炎患者90例分为3组。A组停止用药,B组服用常规剂量埃索美拉唑(20 mg,bid),C组服用小剂量埃索美拉唑(20 mg,隔日1次),第4周和第8周随访反酸、烧心等症状。结果:停药后4周约25%患者复发,第8周时复发率达39.29%;常规剂量和小剂量埃索美拉唑均可降低复发率(P<0.05),第4周时小剂量组预防效果不如常规剂量组(P<0.05),但在第8周时两组效果没有显著差异(P>0.05)。结论:小剂量埃索美拉唑可以有效防止反流性食管炎治愈后复发。
OBJECTIVE: To evaluate the role of small dose esomeprazole in preventing relapse after reflux esophagitis is cured. Methods: From April 2008 to October 2009, 90 patients with reflux esophagitis whose symptoms were completely relieved were treated with proton pump inhibitor in outpatients and inpatients of our hospital. Patients in group A discontinued medication, patients in group B received esomeprazole (20 mg bid), patients in group C received low dose esomeprazole (20 mg every other day), and patients in group 4 followed up for the 8th week Acid, heartburn and other symptoms. Results: About 25% of the patients relapsed after 4 weeks and the recurrence rate was 39.29% at the 8th week. Both the conventional and small doses of esomeprazole could reduce the recurrence rate (P <0.05) The preventive effect was not as good as the conventional dose group (P <0.05), but there was no significant difference between the two groups at the 8th week (P> 0.05). Conclusion: Small doses of esomeprazole can effectively prevent reflux esophagitis recurrence after cure.