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肺动脉高压(pulmonary arterial hypertension,PAH)是一种罕见疾病,其疾病特点为血管增生和重塑所导致的肺动脉阻力进行性增高、右心衰竭和死亡。PAH的发病机制是多因素的,而内皮细胞功能障碍是发病因素之一。其内皮细胞功能障碍的特点是缩血管因子和细胞增生因子(如内皮素1)的
Pulmonary arterial hypertension (PAH) is a rare condition characterized by progressive pulmonary resistance, right heart failure and death due to vascular proliferation and remodeling. PAH pathogenesis is multifactorial, and endothelial cell dysfunction is one of the pathogenesis. Its endothelial cell dysfunction is characterized by vasoconstrictive factors and cell proliferation factors (such as endothelin 1)