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去除或降低某个或某些基因在细胞或机体中的表达 ,是研究正常基因的结构、功能、疾病的发病机制的重要手段。进行这类研究 ,需要在遗传学和分子生物学上有易于控制的实验体系。比如基因敲除 (ｋｎｏｃｋｏｕｔ)或基因表达降低(ｋｎｏｃｋｄｏｗｎ)等方法就成功地对许多特殊基因
Removing or reducing the expression of one or some genes in a cell or body is an important means of studying the structure, function, and pathogenesis of a normal gene. Such research requires an experimental system that is easily controlled in genetics and molecular biology. Such as knockout (knockout) or gene knockdown and other methods successfully on many special genes