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Aim:To investigate the effect of chronic morphine exposure on the receptive fieldproperties of lateral geniculate nucleus(LGN)neurons in cats.Methods:Catswere injected with morphine(10 mg/kg)or saline twice daily,for 10 d.Subsequently,extracellular single-unit recording techniques were used to examine the sensitivityof LGN neurons to visual stimuli in chronic morphine-treated and saline-treatedcats.Results:Compared with saline-treated cats(as controls),LGN neurons inmorphine-treated cats had decreased signal-to-noise ratios(1.9 vs 3.1 ),and orien-tation and direction sensitivity(0.103 vs O.135 and 0.074 vs O.10,respectively),accompanied by significant increases in spontaneous(27.4 vs 17.5)and evokedactivity(preferred:42.2 vs 38.1;average:28.1 vs 22.3).Conclusion:Chronic mor-phine exposure can lead to the functional degradation of LGN neurons in cats,which might result from the effects of chronic morphine exposure on inhibitoryneurotransmission.
Aim: To investigate the effect of chronic morphine exposure on receding field properties of lateral geniculate nucleus (LGN) neurons in cats. Methods: Catswere injected with morphine (10 mg / kg) or saline twice daily, for 10 d. -unit recording techniques were used to examine the sensitivity of LGN neurons to visual stimuli in chronic morphine-treated and saline-treated cats. Results: Compared with saline-treated cats (as controls), LGN neurons inmorphine-treated cats had decreased signal-to- noise ratio (1.9 vs. 3.1), and orien-tation and direction sensitivity (0.103 vs O.135 and 0.074 vs O.10, respectively), accompanied by significant increases in spontaneous (27.4 vs 17.5) and evokedactivity ; average: 28.1 vs 22.3) .Conclusion: Chronic mor-phine exposure can lead to the functional degradation of LGN neurons in cats, which might result from the effects of chronic morphine exposure on inhibitory urotransmission.