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目的观察复方佛耳草合剂联合西医常规疗法治疗痰热郁肺型慢性阻塞性肺疾病(COPD)急性加重期患者的临床疗效。方法选取痰热郁肺型COPD急性加重期患者60例,随机分为治疗组29例和对照组31例。对照组给予常规西药治疗,治疗组在常规西药治疗基础上加服复方佛耳草合剂,疗程均为14天。观察治疗前后症状与体征积分及血清IL-8、IL-2、IFN-γ水平的变化情况,并评价临床疗效。结果①治疗组、对照组总有效率分别为96.55%、74.19%;组间临床疗效比较,差异有统计学意义(P<0.05);②两组咳嗽、咯痰、喘息评分治疗前后组内比较,差异均有统计学意义(P<0.05);组间治疗后比较,各指标评分差异亦均有统计学意义(P<0.05);③两组治疗前后组内比较,IL-2、IL-8及IFN-γ水平差异均有统计学意义(P<0.05);组间治疗后比较,IL-2、IL-8水平差异有统计学意义(P<0.05)。结论复方佛耳草合剂配合常规西药治疗痰热郁肺型COPD急性加重,疗效确切,其机制可能与调节IL-8、IL-2水平有关。
Objective To observe the clinical efficacy of Fufangcao Mixture combined with conventional western medicine in the treatment of patients with acute exacerbation of chronic obstructive pulmonary disease (COPD) caused by phlegm and heat. Methods Sixty patients with acute exacerbations of phlegm and heat lung were selected and randomly divided into treatment group (n = 29) and control group (n = 31). The control group was given routine Western medicine treatment. The treatment group added compound Fudancao mixture on the basis of conventional western medicine treatment for 14 days. The changes of symptoms, signs and serum IL-8, IL-2 and IFN-γ levels before and after treatment were observed and the clinical efficacy was evaluated. Results ① The total effective rates of the treatment group and the control group were 96.55% and 74.19% respectively. There was significant difference between the two groups in the clinical curative effect (P <0.05). ② The comparison of the cough, expectoration and wheezing score before and after treatment in both groups (P <0.05). After treatment, the scores of each index also had statistical significance (P <0.05) .③The levels of IL-2, IL- 8 and IFN-γ levels were significantly different (P <0.05). After treatment, IL-2 and IL-8 levels were significantly different (P <0.05). Conclusion Fufangcao combined with conventional western medicine in the treatment of phlegm and phlegm lung acute exacerbation of acute exacerbation of COPD, the exact effect may be related to the regulation of IL-8, IL-2 levels.