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目的 评价美托洛尔注射液对房室结双径路功能的影响。 方法 11例房室结折返性心动过速的病人在行射频消融术治疗前接受电生理试验 ,比较静推美托洛尔注射液 (0 .1m g/kg)前后房室结双径路前传有效不应期和传导速度的变化。 结果 静推美托洛尔注射液后 ,快径有效不应期由 338.2± 5 6 .4m s延长至 376 .4±5 3.3ms(P<0 .0 1) ,快径路传导速度由 191.8± 48.1ms延长至 2 18.2± 42 .9ms(P<0 .0 5 ) ;慢径路的有效不应期和传导速度在静推美托洛尔注射液后无显著改变。 结论 (1)美托洛尔注射液主要影响快径路的有效不应期和传导速度 ,对慢径路无明显影响。 (2 )推测房室结的快慢径路是由具有不同电生理特性的细胞参与组成。
Objective To evaluate the effect of metoprolol injection on the function of atrioventricular node dual-pathways. Methods Eleven patients with atrioventricular nodal reentrant tachycardia were subjected to electrophysiological test before radiofrequency catheter ablation. Compared with premature rupture of metoprolol injection (0. 1 m g / kg), AV nodal pathway was effective Refraction and conduction velocity changes. Results After intravenous metoprolol injection, the effective fast refractory period increased from 338.2 ± 56.4m to 376.4 ± 5.3ms (P <0.01), and the fast path conduction velocity increased from 191.8 ± 48.1ms to 2 18.2 ± 42.9ms (P <0.05). The effective refractory period and conduction velocity of slow pathway did not change significantly after intravenous metoprolol injection. Conclusion (1) Metoprolol injection mainly affects the effective refractory period and conduction velocity of fast track, but has no obvious effect on slow track. (2) speculated that the atrioventricular node speed path is composed of cells with different electrophysiological characteristics.