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目的 研究乏氧显像剂９９ｍＴｃＨＬ９１ 作为肿瘤阳性显像剂，以及肿瘤坏死对其显像的影响。方法 从人乳腺癌荷瘤裸鼠尾静脉注射９９ｍＴｃＨＬ９１ ７４ ＭＢｑ，采集荷瘤裸鼠图像，处死后测量各脏器、组织和肿瘤的重量和放射性，肿瘤切片，进行放射性自显影和显像。结果 肿瘤显影清晰，注射后６ 小时显像上，肿瘤和头部、胸部的放射性比值分别为２．４４ ±０ ．５３ 、２ ．１３ ±０ ．６４ 。非坏死肿瘤和坏死肿瘤的放射性比值为３７７ ±０ ．３５ 。肿瘤切片的放射性自显影和显像上可见坏死部分放射性低于非坏死部分。肿瘤和腹部、肝脏和肠的放射性比值低。结论 人乳腺癌荷瘤裸鼠的瘤体在９９ｍＴｃＨＬ９１ 显像上为清晰的阳性病灶；坏死肿瘤组织的放射性摄取低于非坏死肿瘤；９９ｍＴｃＨＬ９１在腹部脏器滞留量高，影响其在腹部肿瘤诊断中的应用。
Objective To study the hypoxic imaging agent 99mTc-HL91 as a positive tumor imaging agent and the effect of tumor necrosis on its imaging. Methods The nude mice bearing human breast cancer were injected with 99mTc-HL91 74 MBq in the tail vein. The images of tumor-bearing nude mice were collected. The weight and radioactivity of various organs, tissues and tumors were measured after sacrifice. The tumor sections were autoradiographed and visualized. . Results The tumor was clearly imaged, and the radioactivity ratio of the tumor and head and chest was 2.44 ± 0 at 6 hours after the injection. 53, 2. 13 ±0. 64. The radioactivity ratio of necrotic and necrotic tumors was 377±0. 35. Autoradiography and imaging of tumor sections revealed that necrotic partial radioactivity was lower than non-necrotic ones. The radioactivity ratio between the tumor and the abdomen, liver and intestine is low. Conclusion The tumors of nude mice bearing human breast cancer are clearly positive on 99mTc-HL91 imaging; the radioactivity uptake of necrotic tumors is lower than that of non-necrotic tumors; 99mTc-HL91 has high retention in abdominal organs, affecting The application of abdominal tumor diagnosis.