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目的 :探讨吡柔比星膀胱灌注对浅表性膀胱肿瘤术后复发的预防效果和毒副作用。方法 :选择浅表性膀胱肿瘤患者 ,在行经尿道电切或行膀胱部分切除术后定期经导尿管给予膀胱内灌注吡柔比星 30 mg/ 4 0 m L ,每周 1次 ,每次膀胱内保留 30 m in～ 4 0 m in,共 8次。术后 3月进行 1次膀胱镜检 ,如无复发 ,则进行第 2个疗程的吡柔比星膀胱内灌注 ,方法同第 1个疗程。如发现复发 ,立即安排进行手术。结果 :4 6例共完成 90个疗程的预防灌注。随访 4月～ 2 7月 ,平均 12 .1月。共有 5例复发。 18例患者有尿频、尿急和膀胱区疼痛不适 ,程度较重者 6例 ,但均可耐受继续灌注。结论 :吡柔比星膀胱内灌注预防肿瘤术后复发具有较显著的疗效。吡柔比星的副作用主要表现在局部反应 ,未发现全身性毒性反应。
Objective: To investigate the preventive effect and toxicity of pirarubicin on the postoperative recurrence of superficial bladder tumor. Methods: Patients with superficial bladder tumor were selected. After transurethral resection of the bladder or partial bladder resection, intravesical instillation of pirarubicin 30 mg / 40 m was given regularly through the catheter, once a week Bladder retention 30 m in ~ 4 0 m in, a total of 8 times. A cystoscopy was performed in March after surgery. If there was no recurrence, the second course of pirarubicin intravesical instillation was performed. The first course of treatment was the same. If found recurrence, immediately arranged for surgery. Results: 46 cases completed a total of 90 courses of preventive perfusion. Follow-up from April to July, an average of 12.1 months. A total of 5 cases of recurrence. 18 patients had frequent urination, urinary urgency, and bladder pain and discomfort, the more severe in 6 cases, but can tolerate continued perfusion. Conclusion: Pirarubicin intravesical instillation has a significant effect in preventing recurrence of tumor. Pirarubicin side effects mainly in the local reaction, no systemic toxicity was found.