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目的观察阿托伐他汀钙在治疗颈动脉粥样硬化中对血脂和斑块的影响。方法选取2010年03月至2012年03月本院收治的80例缺血性脑血管病患者为研究对象,随机分为观察组(使用阿托伐他汀钙治疗)和对照组(不使用阿托伐他汀钙治疗),每组各40例,治疗6个月,观察并比较两组血脂水平和颈动脉超声变化情况。结果使用阿托伐他汀钙3个月时,观察组LDL、TG与治疗前比较均明显降低(P<0.05);6个月时,与治疗前和同期对照组比较,观察组TC、TG、LDL均显著降低(P<0.05),而HDL-C显著上升(P<0.05);治疗6个月时观察组颈动脉IMT及其斑块面积较治疗前明显缩小(P均<0.05)。结论阿托伐他汀钙具有改善血脂代谢异常,改善血管内皮功能,稳定粥样斑块的作用。
Objective To observe the effects of atorvastatin calcium on blood lipid and plaque in the treatment of carotid atherosclerosis. Methods Eighty patients with ischemic cerebrovascular disease admitted to our hospital from March 2010 to March 2012 were selected and randomly divided into observation group (treated with atorvastatin calcium) and control group , Statin (50 mg / kg) and statin (50 mg / kg). Forty cases in each group were treated for 6 months. The levels of lipid and carotid artery ultrasound were observed and compared. Results At 6 months, the levels of LDL and TG in observation group were significantly lower than those before treatment (P <0.05). At 6 months, compared with the control group before and after treatment, the levels of TC, TG, LDL decreased significantly (P <0.05), and HDL-C increased significantly (P <0.05). The carotid IMT and plaque area of the observation group decreased significantly (P <0.05) 6 months after treatment. Conclusions Atorvastatin calcium can improve blood lipid metabolism, improve endothelial function and stabilize atherosclerotic plaque.