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发现VitD,并证实其具有抗佝偻病作用,这是本世纪20年代营养学研究领域的重大成就之一。此后又历经60余年的探索,先后阐明了Vit D_2和D_3的化学结构,发现了VitD_3在皮肤内的合成及其代谢通路,证实了VitD必须转变成活性代谢物才能发挥生理效能。近年来又发现,VitD除了对钙、磷代谢的调节作用外,和免疫系统、细胞的分化以及其他内分泌腺体之间都可能有重要的关系。作为营养要素的VitD,由维生素变成内分泌系统的成员,越来越引起人们的重视。
Discovering VitD and demonstrating its anti-rickety effect is one of the major achievements in the field of nutrition research in the 1920s. After more than 60 years of exploration, VitD_2 and D_3 have been elucidated successively, and the synthesis and metabolic pathway of VitD_3 in the skin has been found. It is confirmed that VitD must be transformed into active metabolites to exert its physiological functions. In recent years, VitD has also found that VitD may play an important role in regulating the metabolism of calcium and phosphorus, as well as the immune system, cell differentiation and other endocrine glands. As a nutritional element of VitD, by the vitamin into a member of the endocrine system, more and more aroused people’s attention.