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目的探讨胎盘及血浆uPA的含量与子痫前期发病的关系。方法采用酶联免疫吸附法测定67例子痫前期患者(轻度29例,重度38例)和30例正常晚孕妇女(对照组)胎盘及血浆uPA含量。结果①对照组胎盘uPA含量为(32.62±2.85)ng/g,子痫前期组为(12.42±4.63)ng/g,两组比较差异有统计学意义(P<0.001);重度组明显低于轻度组,差异有极显著性(P<0.001)。②对照组血浆uPA含量为(645.47±41.32)pg/ml,子痫前期组为(461.61±37.68)pg/ml,两组比较差异有显著性(P<0.01);轻、重度组之间比较差异无显著性(P>0.05)。结论子痫前期患者胎盘及血浆uPA含量异常下降与其发病及严重程度有关。
Objective To investigate the relationship between placental and plasma levels of uPA and preeclampsia. Methods The levels of placenta and plasma uPA in 67 preeclampsia patients (29 mild cases, 38 severe cases) and 30 normal pregnant women (control group) were measured by enzyme-linked immunosorbent assay. Results ① The level of uPA in placenta of control group was (32.62 ± 2.85) ng / g and that in preeclampsia group was (12.42 ± 4.63) ng / g, the difference was statistically significant (P <0.001) Mild group, the difference was significant (P <0.001). ② The levels of uPA in the control group were (645.47 ± 41.32) pg / ml and preeclampsia group was (461.61 ± 37.68) pg / ml, there was significant difference between the two groups (P <0.01) There was no significant difference (P> 0.05). Conclusion The abnormal decrease of uPA in placenta and plasma in patients with preeclampsia is related to its onset and severity.