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多种不同的致肿瘤物质可以作用于一系列原癌基因,后者能转化细胞,使其呈现恶性细胞表型。这些基因的正常作用可能是通过它们的产物在生长调节的关键步骤调节细胞的增殖和分化。目前大约鉴定了24种原癌基因,已知c-sis编码血小板生长因子(PDGF)的一条多肽链,c-erb B的编码产物与表皮生长因子(EGF)受体有关。EGF受体是一具有酪氨酸特异性蛋白激酶家族中的一个活性蛋白质
A variety of different tumor-causing substances can act on a series of oncogenes that can transform cells to exhibit a malignant phenotype. The normal role of these genes may be to regulate cell proliferation and differentiation through their products at key steps in the regulation of growth. Currently, about 24 oncogenes have been identified and one polypeptide chain of c-sis encoding platelet-derived growth factor (PDGF) is known. The coding product of c-erb B is involved in the epidermal growth factor (EGF) receptor. The EGF receptor is an active protein with a family of tyrosine-specific protein kinases