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Mitsunobu反应是醇与酸性化合物偶联形成新化学键的一种有效方法,可以用来构建碳-氧、碳-氮、碳-硫及碳-碳等化学键,在天然产物和功能有机分子的合成中已得到了非常广泛的应用.对Mitsunobu反应的机理及其在构建化学键中的应用进行了介绍,并对该反应的区域选择性进行了较为系统的总结.
The Mitsunobu reaction is an effective method to couple new alcohols with acidic compounds to form new chemical bonds. These Mitsunobu reactions can be used to construct chemical bonds such as carbon-oxygen, carbon-nitrogen, carbon-sulfur and carbon-carbon bonds in the synthesis of natural products and functional organic molecules Has been very widely used.The mechanism of Mitsunobu reaction and its application in the construction of chemical bonds are introduced, and the regional selectivity of the reaction is systematically summarized.