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比较了两种测定动物气道反应性的方法： 整体容积描记法和气道内压法。发现前者能测定多个肺通气功能指标， 与临床可比性强， 结果精确， 其中０．１ ｓ用力呼气量 （ＦＥＶ０．１ ） 能较好地反映组胺刺激后气道收缩反应， 与组胺浓度呈显著负相关， 相关系数ｒ＝ －０．９６１； 后者测定方法简便， 重复性好， 能全程动态观察气道内压 （ＩＰ） 及其下降的最大速率（－ｄＩＰ／ｄｔｍ ａｘ） ，可较好反映组胺刺激后气道收缩反应，与组胺浓度呈显著正相关， ｒ分别为０．９６１ 及０．９７３，－ｄＩＰ／ｄｔｍ ａｘ 还可能是一种新的反映小气道功能的敏感指标。
Two methods of determining airway responsiveness in animals were compared: global plethysmography and airway pressure. Found that the former can measure multiple lung ventilation function index, with clinical comparability, the results are accurate, 0.1 s forced expiratory volume (FEV0.1) can better reflect the airway contraction response after histamine stimulation, and group The correlation coefficient r = -0.961. The latter method is simple and reproducible, and can observe the airway pressure (IP) and its maximum rate of decline (-dIP / dtm ax) dynamically. Can better reflect the airway contraction reaction after histamine stimulation, and histamine concentration was significantly positive correlation, r respectively 0.961 and 0.973, -dIP / dtm ax may also be a new reflection of small airway function Sensitive indicators.