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观察含4．6μmol／L巯甲丙脯酸（CPL）的停搏液及再灌注血液对低温体．外循环下犬心脏功能及血流动力学的影响。杂种犬24条，随机分为对照组（停搏液为St．Thomas停搏液改型）、CPL组（含CPL4．6μmol／L的St．Thomas停搏液改型及再灌注血液）及CPL十苯肾上腺素组（基本同CPL组，但在体外循环机内加苯肾上腺素2μg／kg，并在肾动脉开口以下阻断腹主动脉）。结果表明，心脏复跳后CPL组冠状动脉血流量、左心室收缩和舒张功能均明显优于对照组；增加外周血管阻力不影响冠状动脉血流量和心功能指标的恢复率。提示CPL可明显改善缺血再灌注后心功能，其机制可能与抑制心脏局部和体循环系统肾素-血管紧张素系统、抗自由基等作用有关。
To observe the cardioplegia solution containing 4.6μmol / L captopril (CPL) and reperfusion of blood on hypothermia. Cardiac function and hemodynamics in dogs under external circulation. 24 hybrid dogs were randomly divided into control group (cardioplegic solution of St. Thomas cardioplegia modified), CPL group (containing CPL4.6μmol / L St. Thomas cardioplegia modified and reperfused blood) and CPL Decanal-adrenaline group (basically the same as the CPL group, but in the cardiopulmonary bypass machine plus phenylephrine 2μg / kg, and in the renal artery opening below the abdominal aorta). The results showed that coronary blood flow, left ventricular systolic and diastolic function in CPL group were significantly better than those in control group after CPR. Increasing peripheral vascular resistance did not affect the recovery rate of coronary blood flow and cardiac function. These results suggest that CPL can significantly improve cardiac function after ischemia / reperfusion, and its mechanism may be related to the inhibition of renin-angiotensin system and anti-free radical in cardiac and systemic circulatory system.