论文部分内容阅读
Nestin蛋白为第Ⅵ类中间丝蛋白,最初被认为是神经干细胞标志物,表达于神经干/祖细胞、部分成体组织中的前体细胞及细胞修复阶段,还在多种肿瘤细胞中表达,并和P53、Wnt/β-catenin、AktGSK3β-Rb等肿瘤细胞增殖调控信号通路相关。Nestin蛋白在白血病及其他恶性血液肿瘤中异常表达,并且参与急性淋巴白血病(acute lymphoma leukemia,ALL)细胞抗药性niche的形成,以及急性髓系白血病细胞对骨髓微环境的损伤。目前,临床阶段已在白血病和多发性骨髓瘤患者中检测到nestin蛋白表达,其可以作为区分髓系和淋巴系白血病的标志物。在ALL中,敲除nestin可破坏白血病抗药性niche,这可能作为一种治疗ALL的新方法。
Nestin protein is a type VI intermediate filament protein originally thought to be a neural stem cell marker, expressed in neural stem / progenitor cells, progenitor cells in some adult tissues and cell repair phase, and also expressed in a variety of tumor cells And P53, Wnt / β-catenin, AktGSK3β-Rb and other tumor cell proliferation regulatory signaling pathway. Nestin protein is abnormally expressed in leukemias and other hematologic malignancies and is involved in the formation of cell-resistant niche in acute lymphocytic leukemia (ALL) cells and in the bone marrow microenvironment of acute myeloid leukemia cells. Currently, nestin protein expression has been detected in patients with leukemia and multiple myeloma in clinical stage, which can be used as a marker to distinguish myeloid and lymphoid leukemias. Knockout of nestin in ALL can destroy leukemia-resistant niche, which may serve as a novel approach to treat ALL.