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Abstarct: This article addresses the two-dimensional laminar boundary layer flow of magnetohydrodynamic (MHD) Jeffrey nano- fluid with mixed convection. Effects of thermal radiation, thermophoresis, Brownian motion and double stratifications are taken into account. Rosseland’s approximation is utilized for the thermal radiation phenomenon. Convergent series solutions of velocity, tempe- rature and nanoparticle concentration are developed. Graphs of dimensionless temperature and nanoparticle concentration are prese- nted to investigate the influences of different emerging parameters. The values of skin-friction coefficient, local Nusselt and Sherwood numbers are computed and discussed for both Jeffrey and viscous fluids cases. We have observed that the temperature profile retarded for the larger values of Deborah number while an enhancement is noticed with the increasing values of ratio of relaxation to retardation times. Increasing values of thermal and nanoparticle concentration stratifications lead to a reduction in the temperature and nanoparticle concentration. The values of local Nusselt and Sherwood numbers are larger for the viscous fluid case when compared with Jeffrey fluid.