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Ezrin蛋白是ERM蛋白家族中的一员,最早被发现。人体几乎所有的组织细胞中都有Ezrin蛋白的存在。Ezrin蛋白分子通过磷酸化等方式来激活,暴露其分子上的功能位点,形成具有功能分子结构。亚细胞定位在胞浆中,细胞膜与骨架蛋白之间,通过链接细胞内骨架蛋白与膜蛋白来实现其多项复杂而又重要的功能。近年来发现Ezrin蛋白存在多种功能,包括参与细胞形态学、参与免疫突触的形成,与黏附分子作用进而来调节细胞与细胞或细胞与基质间的黏附、调节细胞运动性等。最重要的是它在多种肿瘤中高表达并促进肿瘤细胞的增殖及转移等活动,参与肿瘤的发生与发展。干扰肿瘤细胞内的Ezrin蛋白表达或抑制其磷酸化后,可以明显抑制肿瘤的转移。所以,Ezrin可能成为将来抑制肿瘤转移研究的潜在靶点。
Ezrin protein is a member of ERM protein family, was first discovered. Ezrin protein is present in almost all tissues of the body. Ezrin protein molecules by phosphorylation and other ways to activate, exposing their functional sites on the molecule, the formation of a functional molecular structure. Subcellular localization in the cytoplasm, between the cell membrane and the scaffold protein, by linking intracellular matrix protein and membrane protein to achieve its a number of complex and important functions. In recent years, it has been found that Ezrin protein has multiple functions, including participating in cell morphology, participating in the formation of immune synapse, interacting with adhesion molecules and regulating the adhesion between cells and cells or between cells and matrix, and regulating cell motility. The most important is that it is highly expressed in a variety of tumors and promote tumor cell proliferation and metastasis and other activities involved in the occurrence and development of tumors. Interference with tumor cell Ezrin protein expression or inhibition of its phosphorylation, can significantly inhibit tumor metastasis. Therefore, Ezrin may be a potential target for the future study of tumor metastasis inhibition.