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磷酸咯萘啶(pyronaridine phosphate)是本所1970年合成的疟原虫红内期裂殖体杀灭剂,代号7351。是我国创制的第一个能口服、肌肉注射和静脉滴注多途径给药的化学合成抗疟药。剂型稳定,高效、低毒,与氯喹无交叉抗药性。治疗疟疾疗效显著,也适于治疗抗氯喹株恶性疟和抢救脑型疟等凶险型疟疾。 1 实验疗效 1.1 鼠疟与猴疟疗效 治疗感染伯氏原虫(Plasmodium berghei)敏感株的鼠疟,测得ED_(50)口服为6.8±1.4mg/kg(基质,下同),肌注为4.97±0.65mg/kg;氯喹分别为
Pyronaridine phosphate (pyronaridine phosphate) is a malaria parasite red-late schizontic bactericide synthesized by our institute in 1970, code number 7351. It is the first chemically synthesized anti-malaria drug in our country that can be orally administered, administered intramuscularly and administered intravenously in multiple ways. Formulation stable, efficient, low toxicity, no resistance with chloroquine cross-resistance. Treatment of malaria significant effect, but also suitable for the treatment of chloroquine resistant falciparum malaria and rescue of malaria and other dangerous malaria. 1 Experimental efficacy 1.1 The efficacy of murine malaria and malaria in the treatment of Plasmodium berghei susceptible strains of murine malaria, measured ED_ (50) oral 6.8 ± 1.4mg / kg (matrix, the same below), intramuscular injection of 4.97 ± 0.65mg / kg; chloroquine respectively