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为探求b型流感嗜血杆菌(Hib)荚膜多糖菌苗的长期效果,1974年,作者在芬兰给50,000名3～71月龄婴儿和儿童皮下接种Hib荚膜多糖菌苗21.5μg,6月龄以下婴儿接种半量.1978年,给其中的130名儿童再次接种同剂量菌苗.分别收集接种前后不同时期的血清标本,用放射免疫法测定血清抗-Hib水平.
To explore the long-term effect of Hib capsular polysaccharide vaccine, in 1974, the authors vaccinated 50,000 infants and children aged 3 to 71 months in Finland with 21.5 μg Hib capsular polysaccharide vaccine subcutaneously in June, June One hundred and seventy infants were inoculated with the same dose of vaccine again in 1978. Serum samples were collected at different time points before and after inoculation and anti-Hib levels by radioimmunoassay.