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具有抑制前列腺素合成酶活性的非固醇类抗炎药(non-steroidaI anti-inflammatory drugs,NSAID)广泛用于治疗关节炎患者。而速尿的利尿作用至少部分受肾脏前列腺素的调节。本文报道3例老年心力衰竭(简称心衰)患者,同时使用速尿和 NSAID,结果发生了拮抗现象。其中1例为79岁的缺血性心脏病患者,用速尿80mg/d、地高辛和硝异梨醇治疗心力衰竭达18个月,病情稳定,无水肿。血清尿素和肌酐的浓度分别为21.6mmol/L 和175μmol/L。因腰椎骨关节炎而服用
Non-steroidal anti-inflammatory drugs (NSAIDs) that inhibit prostaglandin synthetase activity are widely used in the treatment of arthritis patients. The diuretic effect of furosemide is at least partially regulated by renal prostaglandins. This article reports 3 cases of elderly patients with heart failure (HF) patients, both furosemide and NSAID, the results of the antagonistic phenomenon. One of the patients was 79 years old with ischemic heart disease, with furosemide 80mg / d, digoxin and nitrendiol for heart failure for 18 months, with stable condition and no edema. Serum urea and creatinine concentrations were 21.6mmol / L and 175μmol / L, respectively. Because of lumbar osteoarthritis and taking