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OBJECTIVE: Gap junction (GJ) is the structural basis for direct intercellular communication of nerve cells. Connexin (Cx) is the protein subunit for constructing GJ channel. Among them, Cx43 is closely related with nervous system. Both Cx43 and nervous system play an important role in the pathophysiological development of hypoxic-ischemic injury. We are in attempt to investigate GJ, Cx43 and their correlations with hypoxic-ischemic brain damage by research. DATA SOURCES: Using the terms “ brain gap junction” in English and “ gap junction” in Chinese, we searched the Medline database and Chinese BioMedical Literature Database as well as China Hospital Knowledge Database to identify the articles published from 1996 to 2006 about GJ and brain hypoxic-ischemic injury. STUDY SELECTION: The articles were selected firstly and abstracts of 250 articles were read through. Articles in which the experimental design met randomized controlled principle were included, and study articles and case reports with repetitive contents were excluded. DATA EXTRACTION: Among 53 included correlative articles, 23 were excluded for repetitive contents and the other 30 were analyzed. DATA SYNTHESIS: GJ, widely existing in nervous system, plays a key role in maintaining normal differentiation and development as well as physiological function of brain tissue. GJ channel is a hydrophilic, low-selectivity and lowohmic channel, which can provide direct channel for intercellular substance transmission and information communication. It plays an important role in the differentiation and development of nerve cells and regulation of physiological function. The functions of GJ channel are regulated by many factors, which involved intracellular pH value, Ca2+ concentration, ATP concentration, phosphorylation of Cx, transchannel pressure, some neurohormonal factors, regulatory factors of protein and so on. Cx43 is the main component of GJ channel in the brain tissues. Its expression in the brain tissue of mammal is the strongest, mainly in astrocytes. Studies demonstrate that gap junctional intercellular communication abnormality and Cx gene change are closely related with the pathophysiological processes of many nervous system diseases. Among them, the intercellular GJ function and Cx43 change of astrocytes are closely related with the pathophysiological development of hypoxic-ischemic brain damage. CONCLUSION: Intercellular GJ function and Cx43 change of astrocytes play a key role in the hypoxic-ischemic brain damage, and they are closely related with the pathophysiological development of hypoxic-ischemic brain damage.
OBJECTIVE: Gap junction (GJ) is the structural basis for direct intercellular communication of nerve cells. Connexin (Cx) is the protein subunit for constructing GJ channel. Among them, Cx43 is closely related with nervous system. Both Cx43 and nervous system play an important roles in the pathophysiological development of hypoxic-ischemic injury. We are in attempt to investigate GJ, Cx43 and their correlations with hypoxic-ischemic brain damage by research. DATA SOURCES: Using the terms “brain gap junction” in English and “gap junction” in Chinese, we searched the Medline database and Chinese BioMedical Literature Database as well as China Hospital Knowledge Database to identify the articles published from 1996 to 2006 about GJ and brain hypoxic-ischemic injury. STUDY SELECTION: The articles were selected first and abstracts of 250 articles were read through. Articles in which the experimental design with randomized controlled principle were included, and study articles and case reports with repetitive contents were excluded. DATA EXTRACTION: Among 53 included correlative articles, 23 were excluded for repetitive contents and the other 30 were analyzed. DATA SYNTHESIS: GJ, widely existing in nervous system, plays a key role in maintaining normal differentiation and development as well as physiological function of brain tissue. GJ channel is a hydrophilic, low-selectivity and lowohmic channel, which can provide direct channel for intercellular substance transmission and information communication. It plays an important role in the differentiation and development of nerve cells and regulation of physiological function. The functions of GJ channel are regulated by many factors, which involve intracellular pH value, Ca2 + concentration, ATP concentration, phosphorylation of Cx, transchannel pressure, some neurohormonal factors, regulatory factors of protein and so on. Cx43 is the main component of GJ channel in the brain tissues. Its expression in the brain tissueof mammals of the strongest, mainly in astrocytes. Studies demonstrate that gap junctional intercellular communication abnormality and Cx gene change are closely related with the pathophysiological processes of many nervous system diseases. Among them, the intercellular GJ function and Cx43 change of astrocytes are closely related with the pathophysiological development of hypoxic-ischemic brain damage. CONCLUSION: Intercellular GJ function and Cx43 change of astrocytes play a key role in the hypoxic-ischemic brain damage, and they are closely related with the pathophysiological development of hypoxic-ischemic brain damage.