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目的研究不同剂量碘化钾摄入不同时间对大鼠骨转换生化指标的影响,间接地推断碘剂量对骨代谢的作用方式与特点。方法采用饲养6、12个月不同剂量高碘及低碘Wistar大鼠模型,以适碘组为对照,观察血清骨钙素(BGP)及尿脱氧吡啶啉(UDPD)尿肌酐(Cr)比值等指标,并经统计学数据处理进行组间比较。结果低碘摄入6个月,无论雌鼠还是雄鼠,其骨形成指标均显著低予对照组,骨吸收指标则显著高于对照组,且骨吸收大于骨形成。高碘摄入6个月,各剂量高碘组血清BGP、尿DPDCr比值与适碘组比较均无差异;高碘摄入12个月,大鼠血清BGP含量变化出现性别差异,即高碘摄入导致雄性大鼠较对照组出现升高的趋势,而雌性大鼠出现减低的趋势(100HI组除外),但各剂量高碘组与对照组比较均无统计学差异(P>0.05)。结论碘缺乏可引起骨代谢异常改变,结果导致骨吸收大于骨形成;由于雄性大鼠峰值骨量的出现较雌性晚,故长期高碘摄入对雄鼠影响小;但对雌性大鼠随不同剂量碘摄入其骨代谢状况不同,尤其是长期超量碘摄入将会对骨代谢产生重大的影响,具有引发骨丢失的潜在危险。
Objective To study the effects of different doses of potassium iodide on the biochemical parameters of bone turnover in rats at different times and to indirectly infer the mode and characteristics of the effect of iodine dose on bone metabolism. Methods High and low iodine Wistar rats at different doses were housed for 6 and 12 months. Urinary creatinine (Cr) ratio of serum osteocalcin (BGP) and urinary deoxyoxypyridine (UDPD) Indicators, and statistical data processing for comparison between groups. Results Low iodine intake for 6 months, both female and male mice, the bone formation index was significantly lower to the control group, the bone absorption index was significantly higher than the control group, and bone resorption than bone formation. High-iodine intake for 6 months, the high dose of iodine group serum BGP, urine DPDCr ratio compared with the appropriate iodine group were no differences; high iodine intake of 12 months, the serum BGP content of the sex difference, ie high iodine However, there was a trend of decrease in female rats (except for 100HI group). However, there was no significant difference between the high iodine group and the control group (P> 0.05). Conclusion Iodine deficiency can lead to abnormal changes of bone metabolism, resulting in greater bone resorption than bone formation. Long-term high iodine intake has little effect on males due to the appearance of peak bone mass in males compared with females. However, The dose of iodine intake of bone metabolism in different conditions, especially long-term excess iodine intake will have a significant impact on bone metabolism, with the potential risk of causing bone loss.