GC-NICI-MS analysis of acetazolamide and other sulfonamide (R-SO2-NH2)drugs as pentafluorobenzyl der

• 作 者: Olga Begou Kathrin Drabert Geo
• 机 构: InstituteofToxicology,DepartmentofChemistry,BIOMIC_AUTh
• 出 处: 药物分析学报:英文版
• 发表日期: 2020年1期
• 关键词: ACETAZOLAMIDE Derivatization Quantification SULFONAMIDES Validation

Acetazolamide(molecular mass(MM),222)belongs to the class of sulfonamides(R-SO2-NH2)and is one of the strongest pharmacological inhibitors of carbonic anhydrase activity.Acetazolamide is excreted unchanged in the urine.Here,we report on the development,va