论文部分内容阅读
目的:观察复方苦参注射液联合化疗治疗晚期恶性肿瘤的近期疗效、不良反应及生活质量变化情况。方法对100例晚期恶性肿瘤(预计生存期>3个月)的患者,随机分为两组,治疗组50例,在化疗同时联合加用复方苦参注射液治疗,7天为1个疗程;对照组50例,单纯给予化疗及对症治疗。两组患者化疗2个疗程后进行疗效评价。结果治疗组有效率为24%,对照组为20%,两者比较差异无统计学意义(P>0.05)。而在治疗后的生活质量比较,有效率治疗组为72%,对照组为48%,差异有统计学意义(P<0.01)。不良反应方面:胃肠道反应及骨髓抑制程度上,治疗组均比对照组反应轻,两者比较差异有统计学意义(P<0.05)。治疗组肝功能异常明显低于对照组。结论:复方苦参注射液联合化疗治疗晚期恶性肿瘤,可有效地减轻化疗毒副作用,提高患者的生活质量。
Objective: To observe the curative effect, adverse reaction and quality of life of compound Kushen injection combined with chemotherapy in the treatment of advanced malignant tumor. Methods A total of 100 patients with advanced malignancy (expected survival> 3 months) were randomly divided into two groups. The treatment group (50 cases) was treated with chemotherapy combined with compound Kushen injection (7 days for one course of chemotherapy) Control group of 50 patients were given chemotherapy and symptomatic treatment. Two groups of patients after 2 cycles of chemotherapy efficacy evaluation. Results The effective rate was 24% in the treatment group and 20% in the control group, with no significant difference between the two groups (P> 0.05). The quality of life after treatment, the effective treatment group was 72%, the control group was 48%, the difference was statistically significant (P <0.01). Adverse reactions: gastrointestinal reactions and bone marrow suppression, the treatment group were lighter than the control group, the difference between the two was statistically significant (P <0.05). Liver dysfunction in the treatment group was significantly lower than that in the control group. Conclusion: Compound Kushen injection combined with chemotherapy for advanced malignant tumors can effectively reduce the side effects of chemotherapy and improve the quality of life of patients.