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背景与目的:结直肠癌肝转移作为最常见的转移途径之一,尚缺乏有效的预测、评估指标,本文即探讨结直肠癌术后肝转移与其临床病理因素的关系。方法:比较术后2年发生肝转移107例Dukes B或C期结直肠癌患者与术后2年无肝转移100例患者的血清CEA水平、分析病理切片分化级别、转移淋巴结、淋巴管侵袭以及静脉侵袭的情况。结果:发生肝转移患者远距离淋巴结转移、淋巴管侵袭及镜下静脉侵袭发生率升高,术后CEA持续升高,与无肝转移组比较有显著性差异(P<0.05)。结论:结直肠癌术中未发现肝转移但有远距离淋巴结转移、淋巴管侵袭或镜下静脉侵袭以及术后CEA持续升高,预示发生肝转移的危险性增加。
BACKGROUND & OBJECTIVE: Liver metastasis of colorectal cancer is one of the most common metastatic pathways. However, there is a lack of effective prediction and evaluation of the indicators. This article is to explore the relationship between postoperative liver metastasis and clinicopathological factors in colorectal cancer. Methods: The serum CEA levels in 107 patients with Dukes B or C colorectal cancer with liver metastasis and 100 patients without liver metastasis 2 years after the operation were compared. The pathological grade, lymph node metastasis and lymphatic vessel invasion were analyzed. Venous invasion. Results: The incidence of distant lymph node metastasis, lymphatic invasion and microscopic vein invasion in patients with liver metastasis increased. The postoperative CEA continued to increase, which was significantly different from those without liver metastasis (P <0.05). Conclusion: No liver metastasis, distant metastasis of lymph nodes, invasion of lymphatic vessels or microscopic vein in colorectal cancer during surgery were found. The CEA increased continuously after operation, indicating the increased risk of liver metastasis.