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目的探讨血清IV型胶原测定在诊断肝纤维化中的应用价值。 方法用ELISA法测定 2 0 9例各型病毒性肝炎患者及 5 3例健康体检者血清IV型胶原的水平。 结果血清IV型胶原水平在慢性肝炎中度患者明显升高 ,以慢性肝炎重度和肝硬化患者最高 ,三组患者与其他组比较差异有显著性 (P <0 .0 1 ) ,其升高程度与肝纤维化程度及肝病的严重程度呈正相关。 结论血清IV型胶原测定可以作为反映慢性肝病纤维化严重程度和预后的指标。
Objective To investigate the value of serum type IV collagen in the diagnosis of liver fibrosis. Methods The levels of serum type IV collagen in 209 patients with various types of viral hepatitis and 53 healthy controls were measured by ELISA. Results The level of serum type IV collagen in patients with chronic hepatitis was significantly higher than those in patients with severe chronic hepatitis and cirrhosis, the difference between the three groups was significant (P <0.01), and the level of serum And liver fibrosis and the severity of liver disease was positively correlated. Conclusion The determination of serum type IV collagen can be used as an index to reflect the severity and prognosis of chronic liver fibrosis.