GENETIC ACTIVITY OF CHLOROQUINE IN FUNGI

• 作 者: FranekiJ. Crebelli R. BratuliN. AlaeviM.
• 机 构: Facultg of Food and Biotechnology,Zagreb,Yugoslavia,Istituto Superiore di Sanita,Rome,Italy,Facultg
• 出 处: 癌变.畸变.突变
• 发表日期: 1991年S1期
• 关键词: cerevisiae Saccharomyces putative diploid overs stationary exponential specifica

The exposure of both stationary and exponential pha-se cells of Saccharomyces cerevisiae diploid strainD6 to 0.15-1.5mg/ml chloroquine (ClQ) produced adose-related increase of putative monosomic,whitecycloheximide resistant colonies,and no increase ofmitotic recombinants (cross-overs).The effect obser-ved was specifically induced in strain D6.In fact,

The exposure of both stationary and exponential pha-se cells of Saccharomyces cerevisiae diploid strain D6 to 0.15-1.5 mg / ml chloroquine (ClQ) produced adose-related increase of putative monosomic, whitecycloheximide resistant colonies, and no increase ofmitotic recombinants (cross-overs) The effect obser-ved was specifically induced in strain D6.In fact,