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分析成人急性髓细胞性白血病(AML)初诊免疫表型与完全缓解(CR)率及缓解期的关系。采用直接免疫荧光标记单克隆抗体(McAb)及流式细胞仪(FCM)检测骨髓白血病细胞免疫表型。显示在AML中各髓系抗原的表达率依次为CD13>CD33>CD45>CD38>CD11b>CD117>CD14;干/祖细胞分化抗原CD34表达率为46%,以M2和M4为最高(63%和66%);M3几乎不表达CD34和HLA-DR;淋系抗原在部分AML中表达阳性;CD117+病例较阴性组具有明显低CR率和短CR期。提示免疫表型的相关研究将提高AML诊断准确性,并将有助于指导AML治疗和判断其预后。
To analyze the relationship between the initial immunophenotype and the rate of complete remission (CR) and remission in adult acute myeloid leukemia (AML). Direct immunofluorescence labeled monoclonal antibody (McAb) and flow cytometry (FCM) detection of myeloid leukemia cell phenotype. The expression rates of myeloid antigens in AML were: CD13> CD33> CD45> CD38> CD11b> CD117> CD14; CD34 expression rate of stem / progenitor cells was 46%, highest was M2 and M4 66%); M3 almost does not express CD34 and HLA-DR; lymphoid antigens were positive in some AML; CD117 + patients had significantly lower CR rate and shorter CR than negative patients. Related studies that suggest an immunophenotype will improve the diagnostic accuracy of AML and will help guide AML treatment and prognosis.