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目的分析淮安市新生儿疾病筛查状况,为提高新生儿疾病筛查的管理水平及干预措施提供依据。方法选择2002年3月-2011年12月在淮安出生的活产新生儿,于出生72h、充分哺乳6次后采足跟血置于滤纸上,进行先天性甲状腺功能低下(CH)和苯丙酮尿症(PKU)筛查。采用时间分辨免疫荧光法检测血片中促甲状腺激素(TSH)和苯丙氨酸(Phe)含量,对TSH≥9mIU/L或Phe≥120μmol/L的可疑新生儿由淮安市新生儿疾病筛查中心召回并进一步确诊。结果共筛查新生儿394 022例,筛查率从2002年的24.60%上升至2011年的96.93%;确诊CH 162例(4.11/万),PKU 50例(1.27/万),淮安市新生儿CH、PKU发病率高于全国平均水平。结论从保健网络着手,提高管理质量,是新生儿疾病筛查工作成功的关键,对提高人口素质有重要意义。
Objective To analyze the status of neonatal disease screening in Huaian City and provide the basis for improving the management level of neonatal disease screening and intervention measures. Methods The live born newborns born in Huai’an from March 2002 to December 2011 were selected. After birth for 72 h and sufficient breastfeeding for 6 times, the heel and blood were placed on the filter paper for congenital hypothyroidism (CH) and propiophenone Urinary disease (PKU) screening. Thyroid-stimulating hormone (TSH) and phenylalanine (Phe) were detected by time-resolved immunofluorescence. Suspected newborns with TSH≥9mIU / L or Phe≥120μmol / L were screened for neonatal disease Center recall and further confirmed. Results A total of 394 022 newborns were screened and the screening rate increased from 24.60% in 2002 to 96.93% in 2011; 162 cases (4.11 / 10 000) were confirmed CH, 50 cases (1.27 / CH, PKU incidence higher than the national average. Conclusion Starting from the health care network to improve the quality of management is the key to the successful screening of neonatal diseases and is of great significance to improving the quality of the population.