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在过去30多年中,许多报道证实有毒金属染毒与高血压的发生有关。饮食中铁、铜和锌水平,可影响铅的吸收和毒性,而铅的摄入可能会改变锌的水平及其某些生物学活性。微量元素锌和铜在维持机体的生命活动中起重要作用,包括维持心血管稳态作用和参与血管肽类的合成和分解代谢。单胺氧化酶和多巴胺—β—羟化酶为含铜酶,通过对血管胺类和神经介质的代谢调节心血管功能。本次研究目的,为观察长期铅染毒是否影响大鼠的血压,及对维持心血管稳态作用有关的微量金属含量的变化。实验选用雄性大鼠,随机分为4组、每组6只。大鼠用含铅低于1.5mg/kg,铜8～15mg
In the past 30 years, many reports confirm that toxic metal exposure is associated with the development of hypertension. Iron, copper and zinc levels in the diet affect lead absorption and toxicity, and lead intake may alter zinc levels and some of its biological activity. Trace elements zinc and copper play an important role in maintaining the life activities of the body, including maintaining cardiovascular homeostasis and participating in the synthesis and catabolism of vascular peptides. Monoamine oxidase and dopamine-β-hydroxylase are copper-containing enzymes that regulate cardiovascular function through the metabolism of vascular amines and neurotransmitters. The purpose of this study was to investigate whether long-term lead exposure affects blood pressure in rats and changes in trace metals associated with maintaining cardiovascular homeostasis. Male rats were randomly divided into 4 groups with 6 rats in each group. Rats with lead less than 1.5mg / kg, copper 8 ~ 15mg