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目的总结手足口病(HFMD)患儿T淋巴细胞亚群的变化趋势,为临床治疗及预后评估提供依据。方法采用流式细胞仪检测2009年3月1日至2011年12月3l日,在南宁市第四人民医院住院的676例手足口病患儿急性期的T淋巴细胞亚群;对其中106例重症及危重症患儿咽拭子和肛试子标本进行RT—PCR以确定病原。对不同样本行独立样本,t检验、配对t检验或方差分析。结果 570例普通病例患儿中555例的急性期T淋巴细胞亚群均数与同龄婴幼儿及儿童正常参考水平一致,仅有15例低于正常均数;106例重症及危重症患儿T淋巴细胞亚群计数较普通病例患儿明显降低,差异有统计学意义。结论 HFMD患儿细胞免疫功能普通组与正常儿童比较没有明显变化,而重症和危重症组明显降低,细胞免疫功能状况可作为判断病情和预后的重要指标,同时对重症及危重症病例临床治疗具有重要指导意义。
Objective To summarize the trend of T lymphocyte subsets in children with HFMD, and provide the basis for clinical treatment and prognosis evaluation. Methods Flow cytometry was used to detect T lymphocyte subsets in 676 children with HFMD who were admitted to the Fourth People’s Hospital of Nanning from March 1, 2009 to December 31, 2011. A total of 106 patients Critically ill and critically ill children throat swabs and anal specimens were RT-PCR to determine the pathogen. Independent samples for different samples, t test, paired t test or analysis of variance. Results The average number of T lymphocyte subsets in 555 children in 570 common cases was the same as the normal reference level of infants and children of the same age, only 15 cases were lower than the normal mean. Among the 106 children with severe and critically ill children, T The count of lymphocyte subsets was significantly lower than that of normal cases, the difference was statistically significant. Conclusions There was no significant difference in the cellular immune function between HFMD children and normal children, but severe and critically ill patients were significantly decreased. The immune function of HFMD children could be used as an important index to judge the disease and prognosis. At the same time, Important guiding significance.