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该研究以金莲花提取物为模型药物,将其制备成粉雾剂,并进行制剂学评价。采用喷雾干燥法制备金莲花提取物微粉;将微粉与乳糖载体混合制备粉雾剂,考察并优化处方与制备工艺。结果表明,金莲花微粉的体外有效部位沉积率为(21.07±1.74)%,排空率为(75.31±21.05)%;与适当的乳糖载体混合后,有效部位沉积率为(56.4±2.2)%,排空率为(95.9±3.0)%。由此可见,所制备的粉雾剂各项指标符合药典相关规定,具有较好的应用前景。
In this study, Trollius officinalis L. extract was taken as a model drug, prepared into a powder aerosol, and evaluated for formulation. The spray-dried method was used to prepare the powder of Trollius quinquera extract; the mixture of the powder and the lactose carrier was used to prepare the powder, and the prescription and the preparation process were optimized. The results showed that the effective deposition rate was (21.07 ± 1.74)% and the emptying rate was (75.31 ± 21.05)%. After mixed with the appropriate lactose carrier, the effective deposition rate was (56.4 ± 2.2)%, , The emptying rate was (95.9 ± 3.0)%. Thus, all the indicators of the prepared powder aerosols comply with the relevant provisions of Pharmacopoeia, and has good application prospects.