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青蒿酯钠系抗疟新药青蒿素的水溶性衍生物。为了全面评价青蒿酯钠的毒性,测定其胚胎毒性目的在于观察母体在妊娠期间使用青蒿酯钠可能引起对胎儿的潜在性危害。 参照Wilson报道的方法,测定了给妊娠Wistar大鼠sc青蒿酯钠的胚胎毒性。试验分为不同阶段给药,结果如下:
Artemisinin sodium water-soluble derivatives of artemisinin, a new anti-malarial drug. In order to fully evaluate the toxicity of artesunate sodium, the purpose of determining its embryotoxicity is to observe that the use of artesunate during pregnancy may cause potential harm to the fetus. Referring to the method reported by Wilson, embryotoxicity of artesunate sodium in pregnant Wistar rats was determined. Tests are divided into different stages of administration, the results are as follows: