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目的 :探讨ＥＢＶ -ＬＭＰ1促进细胞增殖 ,参与ＥＢＶ相关疾病致瘤的分子机制和ＥＢＶ -ＬＭＰ1通过ＮＦκＢ介导的信号传导途径活化细胞周期重要正性调节因子ＣｙｃｌｉｎＤ1表达的机制。方法 :利用已建株的 ,ＬＭＰ1表达受四环素衍生物强力霉素严密调控的ｐＴｅｔ-ｏｎ -ＬＭ
Objective: To investigate the molecular mechanism of EBV-LMP1 promoting cell proliferation, involvement of EBV-related diseases and the mechanism of EBV-LMP1 activation of CyclinD1 expression, an important positive regulator of cell cycle through NFκB-mediated signaling pathway. Methods : Using established strains, LMP1 expressed pTet-on-LM closely controlled by tetracycline derivative doxycycline