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在中国清代文献考证学的影响下,日本从江户时代晚期至明治初期,所谓考证学派对《素问》的研究非常盛行。中国的医书考证是由儒家研究经史发展到子书,进而涉及到医书的。而在日本,代表知识阶级的医家,尤其是江户医学馆的人们,例如江户晚期编辑汉藉书志学的精华《经籍访古志》的涩江全善、森立之,其协力者小岛宝素、小岛春沂(宝索之子)、伊泽柏轩、海保渔村、堀川济等人,多为幕府医官、藩医(即便不是,也至少为医学馆教授)。他们不仅研究《索问》,还致力于其他研究,或《灵枢》,或《伤寒论》,或《金匮要略》,或《神农本草经》,或临床各科古典。也有全面研究者,以其医学知识来从事《素问》研究的。
Under the influence of textual research in Qing Dynasty in China, from the late Edo period to the early Meiji period, the so-called textual research schools are very popular with the study of “prime questions.” The textual research on medical books in China is from the study of Confucianism to the development of history books, which in turn involves medical books. In Japan, physicians representing the intellectual class, especially those at Edo Medical Center, such as the late Edo Edo borrowed the essence of the bibliography of Zhijiang, , Kojima Chunyoshi (son of Po Sousa), Ezekiel Xuan, Haibao fishing village, Horikawa and others, mostly Shogunate medical doctors (if not, but also at least medical school professor). They not only study “ask questions”, but also devote themselves to other studies, or “spiritual pivot” or “Treatise on Febrile Diseases”, or “Golden Chamber” or “Shen Nong’s Materia Medica,” or classical clinical subjects. There are also all-round researchers who, with their medical knowledge, are engaged in the study of “prime questions.”